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Article

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer's disease.

Molecular neurodegeneration - 31 Jan 2020

Williams Tosha, Borchelt David R, Chakrabarty Paramita

Abstract excerpt

One of the primary genetic risk factors for Alzheimer's disease (AD) is the presence of the Ɛ4 allele of apolipoprotein E (APOE). APOE is a polymorphic lipoprotein that is a major cholesterol carrier in the brain. It is also involved in various cellular functions such as neuronal signaling, neuroinflammation and glucose metabolism. Humans predominantly possess three different allelic variants of APOE, termed E2,...

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Identifiers

PMID: 32005122
DOI: 10.1186/s13024-020-0358-9
PMCID: PMC6995170

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