Article
Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury.
Neuroscience - 10 Apr 2009
Crawford F, Wood M, Ferguson S, Mathura V, Gupta P, Humphrey J, Mouzon B, Laporte V, Margenthaler E, O'Steen B, Hayes R, Roses A, Mullan M
Abstract excerpt
The different alleles of the apolipoprotein E gene (APOE-gene, ApoE-protein) have been reported to influence recovery after traumatic brain injury (TBI) in both human patients and animal models, with the e4 allele typically conferring poorer prognosis for recovery. How the E4 allele, and consequently the ApoE4 isoform, affects recovery is unknown, but proposed mechanisms include neurogenesis, inflammatory...
Topics
- Animals
- Apolipoprotein E2
- Apolipoprotein E3
- Apolipoprotein E4
- Brain Injuries
- Cerebral Cortex
- Databases, Genetic
- Female
- Gene Expression Profiling
- Gene Expression Regulation