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Article

Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity.

Tissue antigens - 1 Dec 2003

Berretta F, Butler R H, Diaz G, Sanarico N, Arroyo J, Fraziano M, Aichinger G, Wucherpfennig K W, Colizzi V, Saltini C, Amicosante M

Abstract excerpt

The polymorphism at position beta69 of the human leukocyte antigen (HLA)-DP molecule has been associated with susceptibility to several immune disorders and alloreactivity. Using molecular modeling, we have predicted a detailed structure of the HLA-DP2 molecule (carrying Glubeta69) complexed with class II associated invariant chain derived peptide (CLIP) and compared it with the form carrying Lys at beta69...

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Identifiers

PMID: 14617029
DOI: 10.1046/j.1399-0039.2003.00131.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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