Article
Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity.
Tissue antigens - 1 Dec 2003
Berretta F, Butler R H, Diaz G, Sanarico N, Arroyo J, Fraziano M, Aichinger G, Wucherpfennig K W, Colizzi V, Saltini C, Amicosante M
Abstract excerpt
The polymorphism at position beta69 of the human leukocyte antigen (HLA)-DP molecule has been associated with susceptibility to several immune disorders and alloreactivity. Using molecular modeling, we have predicted a detailed structure of the HLA-DP2 molecule (carrying Glubeta69) complexed with...
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