Article
Molecular basis of TCR selectivity, cross-reactivity, and allelic discrimination by a bacterial superantigen: integrative functional and energetic mapping of the SpeC-Vbeta2.1 molecular interface.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2006
Rahman A K M Nur-ur, Herfst Christine A, Moza Beenu, Shames Stephanie R, Chau Luan A, Bueno Clara, Madrenas Joaquín, Sundberg Eric J, McCormick John K
Abstract excerpt
Superantigens activate large fractions of T cells through unconventional interactions with both TCR beta-chain V domains (Vbetas) and MHC class II molecules. The bacterial superantigen streptococcal pyrogenic exotoxin C (SpeC) primarily stimulates human Vbeta2(+) T cells. Herein, we have analyzed the SpeC-Vbeta2.1 interaction by mutating all SpeC residues that make contact with Vbeta2.1 and have determined the...
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