Article
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.
Blood - 15 Jan 2006
Crawford Jack H, Isbell T Scott, Huang Zhi, Shiva Sruti, Chacko Balu K, Schechter Alan N, Darley-Usmar Victor M, Kerby Jeffrey D, Lang John D, Kraus David, Ho Chien, Gladwin Mark T, Patel Rakesh P
Abstract excerpt
Local vasodilation in response to hypoxia is a fundamental physiologic response ensuring oxygen delivery to tissues under metabolic stress. Recent studies identify a role for the red blood cell (RBC), with hemoglobin the hypoxic sensor. Herein, we investigate the mechanisms regulating this process and explore the relative roles of adenosine triphosphate, S-nitrosohemoglobin, and nitrite as effectors. We provide...
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