Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation.

JCI insight - 8 Feb 2022

Zhang Rongli, Hausladen Alfred, Qian Zhaoxia, Liao Xudong, Premont Richard T, Stamler Jonathan S

Abstract excerpt

Systemic hypoxia is characterized by peripheral vasodilation and pulmonary vasoconstriction. However, the system-wide mechanism for signaling hypoxia remains unknown. Accumulating evidence suggests that hemoglobin (Hb) in RBCs may serve as an O2 sensor and O2-responsive NO signal transducer to regulate systemic and pulmonary vascular tone, but this remains unexamined at the integrated system level. One residue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystatin C
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemoglobins

Share to Hypertension, Pulmonary

Share to Hypoxia

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Vasodilation

Source

Open in PubMed Open full text

Identifiers

PMID: 34914637
DOI: 10.1172/jci.insight.155234
PMCID: PMC8855790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation.PMID 34914637Read ↗

Red Blood Cell-Mediated S-Nitrosohemoglobin-Dependent Vasodilation: Lessons Learned from a β-Globin Cys93 Knock-In MouseSemantic proximity Read ↗

Quercetin Completely Ameliorates Hypoxia-Reoxygenation-Induced Pathophysiology Severity in NY1DD Transgenic Sickle Mice: Intrinsic Mild Steady State Pathophysiology of the Disease in NY1DD Is Also Reversed.Semantic proximity Read ↗

Impaired vasodilation by red blood cells in sickle cell disease.Semantic proximity Read ↗

Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.Semantic proximity Read ↗

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.Semantic proximity Read ↗

Heritable disorders of oxygen sensing.Semantic proximity Read ↗

Heritable disorders of oxygen sensing.Semantic proximity Read ↗

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent <i>S</i> -Nitroso TransferSemantic proximity Read ↗

Therapeutic potential of oxygen through M101 transportation in reducing vaso-occlusion and hemolysis in a mouse model of sickle cell diseaseSemantic proximity Read ↗

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione poolsSemantic proximity Read ↗

A novel mouse model of hemoglobin SC disease reveals mechanisms underlying beneficial effects of hydroxyureaSemantic proximity Read ↗

Partial loss of succinate dehydrogenase reduces high red cell distribution width and promotes healthy survival in chronically hypoxic miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.