Article
Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide.
The Journal of biological chemistry - 1 Jul 2011
Roche Camille J, Malashkevich Vladimir, Balazs Tatiana C, Dantsker David, Chen Qiuying, Moreira Juan, Almo Steven C, Friedman Joel M, Hirsch Rhoda Elison
Abstract excerpt
Hemoglobin (Hb) E (β-Glu26Lys) remains an enigma in terms of its contributions to red blood cell (RBC) pathophysiological mechanisms; for example, EE individuals exhibit a mild chronic anemia, and HbE/β-thalassemia individuals show a range of clinical manifestations, including high morbidity and death, often resulting from cardiac dysfunction. The purpose of this study was to determine and evaluate structural and...
Topics
- Allosteric Regulation
- Catalysis
- Crystallography, X-Ray
- Hemoglobin E
- Humans
- Models, Molecular
- Mutation
- Nitric Oxide
- Oxidation-Reduction
- Oxygen
- Structure-Activity Relationship