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Article

Structural and functional studies indicating altered redox properties of hemoglobin E: implications for production of bioactive nitric oxide.

The Journal of biological chemistry - 1 Jul 2011

Roche Camille J, Malashkevich Vladimir, Balazs Tatiana C, Dantsker David, Chen Qiuying, Moreira Juan, Almo Steven C, Friedman Joel M, Hirsch Rhoda Elison

Abstract excerpt

Hemoglobin (Hb) E (β-Glu26Lys) remains an enigma in terms of its contributions to red blood cell (RBC) pathophysiological mechanisms; for example, EE individuals exhibit a mild chronic anemia, and HbE/β-thalassemia individuals show a range of clinical manifestations, including high morbidity and death, often resulting from cardiac dysfunction. The purpose of this study was to determine and evaluate structural and...

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Identifiers

PMID: 21531715
DOI: 10.1074/jbc.M110.183186
PMCID: PMC3123109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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