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Article

Sickle cell anemia and vascular dysfunction: the nitric oxide connection.

Journal of cellular physiology - 1 Sept 2010

Akinsheye Idowu, Klings Elizabeth S

Abstract excerpt

Endothelial dysfunction and impaired nitric oxide bioavailability have been implicated in the pathogenesis of sickle cell anemia. Nitric oxide is a diatomic gas with a role in vascular homeostasis. Hemoglobin polymerization resulting from the HbS mutation produces erythrocyte deformation and hemolysis. Free hemoglobin, released into plasma by hemolysis scavenges on nitric oxide, and leads to reduced nitric oxide...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20578237
DOI: 10.1002/jcp.22195

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