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Article

Impaired vasodilation by red blood cells in sickle cell disease.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2005

Pawloski John R, Hess Douglas T, Stamler Jonathan S

Abstract excerpt

Red blood cells (RBCs) have been ascribed a unique role in dilating blood vessels, which requires O2-regulated binding and bioactivation of NO by Hb and transfer of NO equivalents to the RBC membrane. Vasoocclusion in hypoxic tissues is the hallmark of sickle cell anemia. Here we show that sickle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15699345
DOI: 10.1073/pnas.0409876102
PMCID: PMC548996

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15699345-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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