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Article

A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation.

Nucleic acids research - 1 Jan 2005

Marie-Egyptienne Delphine T, Cerone Maria Antonietta, Londoño-Vallejo J Arturo, Autexier Chantal

Abstract excerpt

The phylogenetically-derived secondary structures of telomerase RNAs (TR) from ciliates, yeasts and vertebrates are surprisingly conserved and contain a pseudoknot domain at a similar location downstream of the template. As the pseudoknot domains of Tetrahymena TR (tTR) and human TR (hTR) mediate certain similar functions, we hypothesized that they might be functionally interchangeable. We constructed a chimeric...

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Identifiers

PMID: 16192571
DOI: 10.1093/nar/gki848
PMCID: PMC1236975

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