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Article

Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human.

Proceedings of the National Academy of Sciences of the United States of America - 30 Aug 2016

Wang Yaqiang, Yesselman Joseph D, Zhang Qi, Kang Mijeong, Feigon Juli

Abstract excerpt

Telomerase is an RNA-protein complex that includes a unique reverse transcriptase that catalyzes the addition of single-stranded telomere DNA repeats onto the 3' ends of linear chromosomes using an integral telomerase RNA (TR) template. Vertebrate TR contains the template/pseudoknot (t/PK) and CR4/5 domains required for telomerase activity in vitro. All vertebrate pseudoknots include two subdomains: P2ab (helices...

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Identifiers

PMID: 27531956
DOI: 10.1073/pnas.1607411113
PMCID: PMC5024593

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