Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conserved secondary structure for telomerase RNA.

Cell - 18 Oct 1991

Romero D P, Blackburn E H

Abstract excerpt

The RNA moiety of the ribonucleoprotein enzyme telomerase contains the template for telomeric DNA synthesis. We present a secondary structure model for telomerase RNA, derived by a phylogenetic comparative analysis of telomerase RNAs from seven tetrahymenine ciliates. The telomerase RNA genes from Tetrahymena malaccensis, T. pyriformis, T. hyperangularis, T. pigmentosa, T. hegewishii, and Glaucoma chattoni were...

Topics

Animals
Base Composition
Base Sequence
Blotting, Southern
Ciliophora
Cloning, Molecular
DNA Nucleotidylexotransferase
Genetic Variation
Models, Molecular
Molecular Sequence Data
Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

RNA, Nuclear

Ribonucleoproteins

Sequence Alignment

Tetrahymena

Source

Identifiers

PMID: 1840508
DOI: 10.1016/0092-8674(91)90186-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1840508-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved secondary structure for telomerase RNA.PMID 1840508Read ↗

A Phylogenetically Based Secondary Structure for the Yeast Telomerase RNASemantic proximity Read ↗

RNA Binding Domain of Telomerase Reverse TranscriptaseSemantic proximity Read ↗

The conserved structure of plant telomerase RNA provides the missing link for an evolutionary pathway from ciliates to humansSemantic proximity Read ↗

A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase proteinSemantic proximity Read ↗

The telomerase database.Semantic proximity Read ↗

A new telomerase RNA element that is critical for telomere elongation.Semantic proximity Read ↗

Identification of an essential proximal sequence element in the promoter of the telomerase RNA gene of Tetrahymena thermophila.Semantic proximity Read ↗

A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation.Semantic proximity Read ↗

The common ancestral core of vertebrate and fungal telomerase RNAsSemantic proximity Read ↗

Molecular and Evolutionary Analysis of RNA–Protein Interactions in Telomerase RegulationSemantic proximity Read ↗

Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function.Semantic proximity Read ↗

Evolution of plant telomerase RNAs: farther to the past, deeper to the roots.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.