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Article

Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis.

Addiction biology - 1 Jun 2005

Ohgake Shintaro, Hashimoto Kenji, Shimizu Eiji, Koizumi Hiroki, Okamura Naoe, Koike Kaori, Matsuzawa Daisuke, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Shirayama Yukihiko, Iyo Masaomi

Abstract excerpt

Several lines of evidence suggest that genetic factors contribute to the vulnerability of drug abuse such as methamphetamine (MAP), and that dopamine-quinones produced by administration of MAP may be involved in the mechanism of MAP-related symptoms. The detoxification of quinones is catalyzed by a family of proteins designated as quinone oxidoreductases (NQOs). We analysed the polymorphisms of NQO1 and NQO2...

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Source

Identifiers

PMID: 16191666
DOI: 10.1080/13556210500123423

Genes

NQO2
NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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