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Article

DAT polymorphism and diverse clinical manifestations in methamphetamine abusers.

Psychiatric genetics - 1 Mar 2004

Liu Hsing-Cheng, Lin Shih-Ku, Liu Shih-Kai, Chen Su-Lien, Hu Chaur-Jong, Chang Jan-Gowth, Leu Sy-Jye

Abstract excerpt

The clinical outcome for methamphetamine (MAP) abusers is variable. MAP exerts its biological activity through rapid conversion to amphetamine (AP) and MAP itself. The dopamine transporter (DAT) is the main modulator of MAP/AP-induced dopamine release and dopamine neurotoxicity, and is also the major regulator of dopamine level in the brain. We tested for an association between a DAT-gene polymorphism and...

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PMID: 15091313
DOI: 10.1097/00041444-200403000-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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