Article
Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers.
Annals of the New York Academy of Sciences - 1 Oct 2008
Ezaki Norikazu, Nakamura Kazuhiko, Sekine Yoshimoto, Thanseem Ismail, Anitha Ayyappan, Iwata Yasuhide, Kawai Masayoshi, Takebayashi Kiyokazu, Suzuki Katsuaki, Takei Nori, Iyo Masaomi, Inada Toshiya, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Mori Norio
Abstract excerpt
Accumulating evidence suggests that genetic factors contribute to the vulnerability to methamphetamine (MAP) abuse and associated psychiatric symptoms. Chronic MAP abuse leads to psychosis, which may be of a transient or a prolonged type. Serotonergic dysfunction has been proposed as one of the contributory factors in the development of MAP psychosis. Our PET studies revealed that the serotonin transporter...
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