Article
A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 May 2005
Hashimoto Tasuku, Hashimoto Kenji, Matsuzawa Daisuke, Shimizu Eiji, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio, Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro, Ujike Hiroshi, Iyo Masaomi
Abstract excerpt
Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione S-transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates...
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