Article
β1 adrenergic receptor polymorphisms and heart failure: a meta-analysis on susceptibility, response to β-blocker therapy and prognosis.
PloS one - 1 Jan 2012
Liu Wen-Nan, Fu Kai-Li, Gao Hai-Yang, Shang Yuan-Yuan, Wang Zhi-Hao, Jiang Gui-Hua, Zhang Yun, Zhang Wei, Zhong Ming
Abstract excerpt
AIMS: The risk stratification of patients for heart failure (HF) remains a challenge, as well as the anticipation of the response to β-blocker therapy. Since the pivotal role of β1 adrenergic receptor (β1-AR) in HF, many publications have studied the associations between the β1-AR polymorphisms (Ser49Gly and Arg389Gly) and HF, with inconsistent results. Thus, we performed a meta-analysis of studies to evaluate...
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