Article
Beta1- and beta2-adrenergic receptor polymorphisms affect susceptibility to idiopathic dilated cardiomyopathy.
Journal of cardiovascular medicine (Hagerstown, Md.) - 1 Aug 2007
Forleo Cinzia, Sorrentino Sandro, Guida Pietro, Romito Roberta, De Tommasi Elisabetta, Iacoviello Massimo, Pitzalis Mariavittoria
Abstract excerpt
OBJECTIVE: Beta1- and beta2-adrenergic receptors (ARs) play a pivotal role in myocardial function. We investigated whether functionally relevant polymorphisms within the genes encoding for these receptors indicate susceptibility to idiopathic dilated cardiomyopathy (DCM). METHODS: This case-control association study involved 189 patients with DCM and 378 gender- and age-matched control subjects. All of the...
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