Article
Role of beta1- and beta2-adrenoceptor polymorphisms in heart failure: a case-control study.
European heart journal - 1 Sept 2004
Covolo Loredana, Gelatti Umberto, Metra Marco, Nodari Savina, Piccichè Antonio, Pezzali Natalia, Zani Claudia, Alberti Adriana, Donato Francesco, Nardi Giuseppe, Dei Cas Livio
Abstract excerpt
BACKGROUND: We hypothesised that the polymorphisms of the genes encoding for beta1- and the beta2-adrenoceptors may have a role in the pathogenesis of heart failure (HF). We therefore compared the polymorphisms of the beta1-adrenoceptor gene (Arg389Gly), the beta2-adrenoceptor gene (Arg16Gly, Gln27Glu) and their combinations in patients with HF and normal subjects living in the same area. METHODS AND RESULTS: A...
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