Article
[Interactions between beta1 and beta2 adrenergic receptor polymorphisms as risk factors for chronic heart failure].
Revista medica de Chile - 1 Nov 2008
Moraga Francisco, Troncoso Rodrigo, Mellado Rosemarie, Díaz-Araya Guillermo, Vukasovic José Luis, Greig Douglas, Perez Osvaldo, García Lorena, Roldán Juan, Ocaranza María Paz, Jali Jorge, Chiong Mario, Castro Pablo
Abstract excerpt
BACKGROUND: Beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostasis. Among these, beta1 and beta2 AR regulate cardiac contractility and frequency and are important pharmacological targets. AIM: To evaluate genotype and gene-gene interaction between beta1-AR Arg389Gly and beta2-AR Arg16Gly, Gln27Glu and Thr164Ile polymorphisms, as risk factors for HF. MATERIAL...
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