Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

The Journal of biological chemistry - 25 Jun 1992

Ding R, Pommier Y, Kang V H, Smulson M

Abstract excerpt

The effects of inducible expression of poly(ADP-ribose) polymerase (PADPRP) antisense RNA in HeLa cells were determined in order to gain further insight into the biological roles of the poly(ADP-ribosyl)ation modification of nuclear proteins. A recombinant expression plasmid was prepared with the mouse mammary tumor virus (MMTV) promoter upstream of the antisense-oriented PADPRP cDNA. Expression of the antisense...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to DNA Repair
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Immunohistochemistry

Share to Kinetics

Share to Phenotype

Share to Transfection

Source

Identifiers

PMID: 1618781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.PMID 1618781Read ↗

trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon.Semantic proximity Read ↗

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1Semantic proximity Read ↗

Increased sensitivity to DNA-alkylating agents in CHO mutants with decreased poly(ADP-ribose) polymerase activity.Semantic proximity Read ↗

Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcriptsSemantic proximity Read ↗

Antisense RNA inhibition of HPRT synthesis.Semantic proximity Read ↗

Role of polyadenylated RNA sequences (POLADS) in vaccinia virus infection: correlation between accumulation of POLADS and extent of shut-off in infected cells.Semantic proximity Read ↗

Isolation and characterization of polyadenylation complexes assembled in vitro.Semantic proximity Read ↗

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers.Semantic proximity Read ↗

Isolation of Chinese hamster ovary cells with reduced poly(ADP-ribose) polymerase activity.Semantic proximity Read ↗

Camptothecin-stabilized topoisomerase I-DNA adducts cause premature termination of transcriptionSemantic proximity Read ↗

NAD(+)-dependent repair of damaged DNA by human cell extracts.Semantic proximity Read ↗

Antisense inhibition of vitamin D receptor expression induces apoptosis in monoblastoid U937 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.