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Article

Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.

The Journal of biological chemistry - 25 Jun 1992

Ding R, Pommier Y, Kang V H, Smulson M

Abstract excerpt

The effects of inducible expression of poly(ADP-ribose) polymerase (PADPRP) antisense RNA in HeLa cells were determined in order to gain further insight into the biological roles of the poly(ADP-ribosyl)ation modification of nuclear proteins. A recombinant expression plasmid was prepared with the mouse mammary tumor virus (MMTV) promoter upstream of the antisense-oriented PADPRP cDNA. Expression of the antisense...

Topics

Cloning, Molecular
DNA Damage
DNA Repair
Deoxyribonuclease I
Dexamethasone
Genetic Vectors
HeLa Cells
Humans
Hydrogen-Ion Concentration
Immunohistochemistry
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Poly(ADP-ribose) Polymerases

RNA, Antisense

Transfection

Source

Identifiers

PMID: 1618781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1618781-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.PMID 1618781Read ↗

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