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Article

NAD(+)-dependent repair of damaged DNA by human cell extracts.

1 Mar 1993

Abstract excerpt

Rejoining of DNA single-strand breaks generated by treatment of plasmids with gamma-rays, neocarzinostatin, or bleomycin was catalyzed inefficiently by human cell extracts. The reaction was strongly promoted by the addition of NAD+, which was employed for rapid and transient synthesis of poly(ADP-ribose). The DNA rejoining reaction was accompanied by DNA repair replication, apparently due to replacement of...

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PMID: 7680646
DOI: 10.1016/s0021-9258(18)53346-9

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NAD(+)-dependent repair of damaged DNA by human cell extracts.PMID 7680646Read ↗

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