Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts

Abstract excerpt

Antisense RNA may regulate the expression of a number of eukaryotic genes, but little is known about its prevalence or mechanism of action. We have used a model system in which antisense control can be studied both genetically and biochemically. Late in polyoma virus infection, early-strand mRNA levels are down-regulated by nuclear antisense RNA from the late strand. Analysis of early-strand transcripts isolated...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA regulation and disease
• Share to RNA Research and Splicing
• Share to Viral Infections and Immunology Research