Role of polyadenylated RNA sequences (POLADS) in vaccinia virus infection: correlation between accumulation of POLADS and extent of shut-off in infected cells.

Abstract excerpt

The selective inhibition of host-cell protein synthesis was studied in cells infected with vaccinia virus (VV) under aberrant conditions of transcription. Previous studies in our laboratory have correlated this selective inhibition with a class of short polyadenylated virus-directed RNAs (POLADS) which are synthesized in VV-infected cells during the early phase of transcription. Moreover, it was shown that...

Topics

• Adenosine
• Animals
• Dactinomycin
• HeLa Cells
• Humans
• L Cells
• Mice
• Mutation
• Poly A
• Protein Biosynthesis
• Proteins
• RNA