Article
Antisense inhibition of vitamin D receptor expression induces apoptosis in monoblastoid U937 cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1996
Hewison M, Dabrowski M, Vadher S, Faulkner L, Cockerill F J, Brickell P M, O'Riordan J L, Katz D R
Abstract excerpt
The active vitamin D3 metabolite 1,25-dihydroxycholecalciferol (1,25(OH)2D3) acts as an antiproliferative and differentiating agent for the monoblastoid cell line U937 and as an important immunologic mediator implicated particularly in the function of cells belonging to the monocyte/macrophage lineage. These effects are controlled by the vitamin D receptor (VDR), a member of the steroid hormone receptor family....
Topics
- Actins
- Apoptosis
- Base Sequence
- Calcitriol
- Cell Cycle
- Cell Line
- DNA
- DNA Primers
- DNA, Complementary
- Humans
- Molecular Sequence Data
- Monocytes
- Phenotype
- RNA, Antisense
- RNA, Messenger
- Receptors, Calcitriol
- Transfection