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DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1

17 Jun 2013

Abstract excerpt

RNA synthesis and DNA replication cease after DNA damage. We studied RNA synthesis using an in situ run-on assay and found ribosomal RNA (rRNA) synthesis was inhibited 24 h after UV light, gamma radiation or DNA cross-linking by cisplatin in human cells. Cisplatin led to accumulation of cells in S phase. Inhibition of the DNA repair proteins DNA-dependent protein kinase (DNA-PK) or poly(ADP-ribose) polymerase 1...

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PMID: 23775790
DOI: 10.1093/nar/gkt502

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