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Article

GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene.

The Journal of biological chemistry - 25 Nov 2005

Gallagher Patrick G, Liem Robert I, Wong Ellice, Weiss Mitchell J, Bodine David M

Abstract excerpt

Alpha-hemoglobin-stabilizing protein (AHSP) is an erythroid protein that binds and stabilizes alpha-hemoglobin during normal erythropoiesis and in pathological states of alpha-hemoglobin excess. AHSP has been proposed as a candidate gene in some Heinz body hemolytic anemias and as a modifier gene in the beta-thalassemia syndromes. To gain additional insight into the molecular mechanisms controlling the...

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Source

Identifiers

PMID: 16186125
DOI: 10.1074/jbc.M506062200

Genes

AHSP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene.PMID 16186125Read ↗

Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.Semantic proximity Read ↗

3’HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expressionSemantic proximity Read ↗

Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.Semantic proximity Read ↗

Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemiaSemantic proximity Read ↗

3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression.Semantic proximity Read ↗

Distinct modes of gene regulation by a cell-specific transcriptional activator.Semantic proximity Read ↗

Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cellsSemantic proximity Read ↗

A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease.Semantic proximity Read ↗

Sequences downstream of the erythroid promoter are required for high level expression of the human alpha-spectrin gene.Semantic proximity Read ↗

Alpha-haemoglobin stabilising protein is a quantitative trait gene that modifies the phenotype of beta-thalassaemia.Semantic proximity Read ↗

Defining a cohort of anemia-activated cis elements reveals a mechanism promoting erythroid precursor functionSemantic proximity Read ↗

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