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Article

Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.

Annals of the New York Academy of Sciences - 1 Jan 2005

Weiss Mitchell J, Zhou Suiping, Feng Liang, Gell David A, Mackay Joel P, Shi Yigong, Gow Andrew J

Abstract excerpt

Hemoglobin (Hb) synthesis is coordinated by homeostatic mechanisms to limit the accumulation of free alpha or beta subunits, which are cytotoxic. Alpha hemoglobin-stabilizing protein (AHSP) is an abundant erythroid protein that specifically binds free alphaHb, stabilizes its structure, and limits its ability to participate in chemical reactions that generate reactive oxygen species. Gene ablation studies in mice...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16339656
DOI: 10.1196/annals.1345.013

Genes

AHSP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.PMID 16339656Read ↗

Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemiaSemantic proximity Read ↗

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Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.Semantic proximity Read ↗

Alpha hemoglobin stabilizing protein: Its causal relationship with the severity of beta thalassemia.Semantic proximity Read ↗

A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease.Semantic proximity Read ↗

Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.Semantic proximity Read ↗

Hemoglobin Variants as Targets for Stabilizing DrugsSemantic proximity Read ↗

Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.Semantic proximity Read ↗

Analysis of human alpha globin gene mutations that impair binding to the alpha hemoglobin stabilizing protein.Semantic proximity Read ↗

Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia.Semantic proximity Read ↗

Evaluation of the free α-hemoglobin pool in red blood cells: a new test providing a scale of β-thalassemia severity.Semantic proximity Read ↗

α-Haemoglobin stabilising protein expression is influenced by mean cell haemoglobin and HbF levels in HbE/β-thalassaemia individuals.Semantic proximity Read ↗

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