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Article

A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease.

Annals of hematology - 1 Jun 2017

Surapolchai Pacharapan, Chuansumrit Ampaiwan, Sirachainan Nongnuch, Kadegasem Praguywan, Leung Ka-Chun, So Chi-Chiu

Abstract excerpt

The clinical course of hemoglobin H (HbH) disease is remarkably variable. It is not completely clear how genetic and environmental factors interplay to modify clinical severity in affected individuals. Previous studies suggested that altered structure or function of alpha-hemoglobin-stabilizing protein (AHSP) could modify the clinical phenotypes of thalassemias. The present study attempted to explore the...

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Identifiers

PMID: 28337528
DOI: 10.1007/s00277-017-2978-x

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AHSP

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