Article

3’HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

2021-05-18

Abstract excerpt

<h4>Summary</h4> Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named Hereditary Persistence of Fetal Hemoglobin (HPFH), has been found to ameliorate hemoglobinopathies. Deletional HPFH occurs through the excision of a significant portion of the 3’ end of...

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Literature Corpus work: cccb7b74-58e2-5aa2-9247-ee6db6b1de71
DOI: 10.1101/2021.05.18.444713

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