Article
Distinct modes of gene regulation by a cell-specific transcriptional activator.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2009
Sengupta Tanushri, Cohet Nathalie, Morlé François, Bieker James J
Abstract excerpt
The architectural layout of a eukaryotic RNA polymerase II core promoter plays a role in general transcriptional activation. However, its role in tissue-specific expression is not known. For example, differing modes of its recognition by general transcription machinery can provide an additional layer of control within which a single tissue-restricted transcription factor may operate. Erythroid Kruppel-like factor...
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