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Article

3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression.

eLife - 29 Sept 2021

Himadewi Pamela, Wang Xue Qing David, Feng Fan, Gore Haley, Liu Yushuai, Yu Lei, Kurita Ryo, Nakamura Yukio, Pfeifer Gerd P, Liu Jie, Zhang Xiaotian

Abstract excerpt

Mutations in the adult β-globin gene can lead to a variety of hemoglobinopathies, including sickle cell disease and β-thalassemia. An increase in fetal hemoglobin expression throughout adulthood, a condition named hereditary persistence of fetal hemoglobin (HPFH), has been found to ameliorate hemoglobinopathies. Deletional HPFH occurs through the excision of a significant portion of the 3' end of the β-globin...

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Identifiers

PMID: 34585664
DOI: 10.7554/eLife.70557
PMCID: PMC8500713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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