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Mechanisms of Globin Gene Regulation in Mammals

20 Aug 2025

Abstract excerpt

Studies of globin gene clusters have established many paradigms of gene regulation. This review focuses on the α- and β-globin gene clusters of humans and mice, summarizing important insights from high-throughput biochemical assays and directed genetic dissections and emphasizing similarities across the types of gene clusters and between species. The overall arrangements and architectures are similar, with each...

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PMID: 40829781
DOI: 10.1146/annurev-genet-020325-095743

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