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Article

Conservation of spermatogonial stem cell self-renewal signaling between mouse and rat

23 Sept 2005

Abstract excerpt

Self-renewal of spermatogonial stem cells (SSCs) is the foundation for maintenance of spermatogenesis throughout life in males and for continuation of a species. The molecular mechanism underlying stem cell self-renewal is a fundamental question in stem cell biology. Recently, we identified growth factors necessary for self-renewal of mouse SSCs and established a serum-free culture system for their proliferation...

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PMID: 16183739
DOI: 10.1073/pnas.0506970102

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