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Article

Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal.

Stem cell reports - 10 Mar 2015

Takashima Seiji, Kanatsu-Shinohara Mito, Tanaka Takashi, Morimoto Hiroko, Inoue Kimiko, Ogonuki Narumi, Jijiwa Mayumi, Takahashi Masahide, Ogura Atsuo, Shinohara Takashi

Abstract excerpt

Spermatogonial stem cells (SSCs) are required for spermatogenesis. Earlier studies showed that glial cell line-derived neurotrophic factor (GDNF) was indispensable for SSC self-renewal by binding to the GFRA1/RET receptor. Mice with mutations in these molecules showed impaired spermatogenesis, which was attributed to SSC depletion. Here we show that SSCs undergo GDNF-independent self-renewal. A small number of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25684228
DOI: 10.1016/j.stemcr.2015.01.010
PMCID: PMC4375941

Genes

GDNF
FGF2
GFRA1
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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