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Article

Regulation of spermatogonial stem cell self-renewal in mammals.

Annual review of cell and developmental biology - 1 Jan 2008

Oatley Jon M, Brinster Ralph L

Abstract excerpt

Mammalian spermatogenesis is a classic adult stem cell-dependent process, supported by self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs provides a model to better understand adult stem cell biology, and deciphering the mechanisms that control SSC functions may lead to treatment of male infertility and an understanding of the etiology of testicular germ cell tumor formation....

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Identifiers

PMID: 18588486
DOI: 10.1146/annurev.cellbio.24.110707.175355
PMCID: PMC4066667

Genes

GDNF

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