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Spermatogonial Stem Cell Self-Renewal and Development

6 Oct 2013

Abstract excerpt

Spermatogenesis originates from spermatogonial stem cells (SSCs). Development of the spermatogonial transplantation technique in 1994 provided the first functional assay to characterize SSCs. In 2000, glial cell line-derived neurotrophic factor was identified as a SSC self-renewal factor. This discovery not only provided a clue to understand SSC self-renewing mechanisms but also made it possible to derive...

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PMID: 24099084
DOI: 10.1146/annurev-cellbio-101512-122353

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