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Wnt5a is a cell-extrinsic factor that supports self-renewal of mouse spermatogonial stem cells

22 Jun 2011

Abstract excerpt

The maintenance of spermatogonial stem cells (SSCs) provides the foundation for life-long spermatogenesis. Although glial-cell-line-derived neurotrophic factor and fibroblast growth factor 2 are crucial for self-renewal of SSCs, recent studies have suggested that other growth factors have important roles in controlling SSC fate. Because β-catenin-dependent Wnt signaling promotes self-renewal of various stem cell...

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PMID: 21693582
DOI: 10.1242/jcs.080903

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