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Article

FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation of<i>Etv5</i>and<i>Bcl6b</i>through MAP2K1 activation

6 Apr 2012

Abstract excerpt

Fibroblast growth factor 2 (FGF2) and glial cell line-derived neurotrophic factor (GDNF) are required to recapitulate spermatogonial stem cell (SSC) self-renewal in vitro. Although studies have revealed the role of the GDNF signaling pathway in SSCs, little is known about how FGF2 is involved. In the present study, we assessed the role of the FGF2 signaling pathway using a mouse germline stem (GS) cell culture...

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PMID: 22491947
DOI: 10.1242/dev.076539

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