Article
p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis.
Oncogene - 1 Oct 1994
Saitoh S, Cunningham J, De Vries E M, McGovern R M, Schroeder J J, Hartmann A, Blaszyk H, Wold L E, Schaid D, Sommer S S
Abstract excerpt
We determined the pattern of mutations in exons 2-11 and adjacent intronic regions in breast cancers from Midwestern US white women. Twenty-one mutations were detected in 53 tumors (39.6%). Comparisons of the pattern of mutations within exons 5-9 showed that the frequency of missense mutations (4...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Breast Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutation
- Prognosis
- Sequence Deletion
- United States