Article
p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis.
Oncogene - 1 Oct 1994
Saitoh S, Cunningham J, De Vries E M, McGovern R M, Schroeder J J, Hartmann A, Blaszyk H, Wold L E, Schaid D, Sommer S S
Abstract excerpt
We determined the pattern of mutations in exons 2-11 and adjacent intronic regions in breast cancers from Midwestern US white women. Twenty-one mutations were detected in 53 tumors (39.6%). Comparisons of the pattern of mutations within exons 5-9 showed that the frequency of missense mutations (44%) was lower in breast cancers of US Midwestern women than in most tumor types including breast cancers in other...
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