Article
ApoE -491A/T promoter polymorphism is not an independent risk factor, but associated with the epsilon4 allele in Hungarian Alzheimer's dementia population.
Neurochemical research - 1 May 2005
Juhász Anna, Palotás András, Janka Zoltán, Rimanóczy Agnes, Palotás Miklós, Bódi Nikoletta, Boda Krisztina, Zana Marianna, Vincze Gábor, Kálmán János
Abstract excerpt
Apolipoprotein E gene (Apo(epsilon)) has three common alleles (epsilon2, epsilon3, and epsilon4), of which epsilon4 has been shown to be associated with an increased risk for Alzheimer's disease (AD). Possible additional genetic factors, like the -491A variant of ApoE promoter may modify the development of AD, independently of the ApoE allele status. The objective of this study was to investigate whether A/T...
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