Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease.

Neuroscience letters - 25 May 2001

Alvarez-Arcaya A, Combarros O, Llorca J, Sánchez-Guerra M, Berciano J, Fernández-Luna J L

Abstract excerpt

Homozygosity for the A allele of the -491 A/T apolipoprotein E (APOE) promoter polymorphism has recently been reported to be associated with sporadic Alzheimer's disease (AD). Two hundred and fifty one patients with AD and an equal number of controls derived from the same region in a Spanish population, were genotyped for -491 A/T and epsilon2/epsilon3/epsilon4 APOE polymorphisms. We did not detect an elevated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Gene Frequency

Share to Homozygote

Share to Odds Ratio

Share to Promoter Regions, Genetic

Share to Reference Values

Source

Identifiers

PMID: 11343837
DOI: 10.1016/s0304-3940(01)01790-6

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease.PMID 11343837Read ↗

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.Semantic proximity Read ↗

The -491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEepsilon4 allele and Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis.Semantic proximity Read ↗

The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease.Semantic proximity Read ↗

ApoE -491A/T promoter polymorphism is not an independent risk factor, but associated with the epsilon4 allele in Hungarian Alzheimer's dementia population.Semantic proximity Read ↗

The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease.Semantic proximity Read ↗

The APOE-491 A/T promoter polymorphism effect on cognitive profile of Alzheimer's patients.Semantic proximity Read ↗

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study.Semantic proximity Read ↗

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk.Semantic proximity Read ↗

Apolipoprotein E -491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population.Semantic proximity Read ↗

Apolipoprotein gene E4 allele promoter polymorphisms as risk factors for Alzheimer's disease.Semantic proximity Read ↗

Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.