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Article

Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner.

Journal of neuroscience research - 15 Oct 2005

Fassa Angeliki, Mehta Pankaj, Efthimiopoulos Spiros

Abstract excerpt

We hypothesized that the physical interaction between the amyloid precursor protein (APP) and Notch 1 (N1) may be mediating the reported cross-talk between the respective signaling pathways. Immunoprecipitation of mouse N1 (mN1) or extracellular domain truncated mN1 (mN1-TM, mimics TACE-produced membrane-bound C-terminal fragment) specifically coprecipitated APP(751). Conversely, immunoprecipitation of APP(751)...

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Source

Identifiers

PMID: 16175584
DOI: 10.1002/jnr.20642

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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