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Article

Pancortins interact with amyloid precursor protein and modulate cortical cell migration

20 Sept 2012

Abstract excerpt

Neuronal precursor cell migration in the developing mammalian brain is a complex process requiring the coordinated interaction of numerous proteins. We have recently shown that amyloid precursor protein (APP) plays a role in migration into the cortical plate through its interaction with two cytosolic signaling proteins, disabled 1 (DAB1) and disrupted in schizophrenia 1 (DISC1). In order to identify extracellular...

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PMID: 22992957
DOI: 10.1242/dev.082909

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