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Article

Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1.

Journal of neuroscience research - 15 Oct 2000

Nakajima M, Shimizu T, Shirasawa T

Abstract excerpt

We prepared a cleavage site-directed antibody against Notch-1, that specifically recognized the cleaved Notch-1 intracellular domain (NICD). To assess Notch-1 processing and its nuclear localization in familial Alzheimer's disease (FAD)-linked presenilin-1 (PS-1) mutants, we overexpressed wild ty...

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Identifiers

PMID: 11020224
DOI: 10.1002/1097-4547(20001015)62:2<311::AID-JNR16>3.0.CO;2-G

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11020224-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1.PMID 11020224Read ↗

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.Semantic proximity Read ↗

A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling.Semantic proximity Read ↗

Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.Semantic proximity Read ↗

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.Semantic proximity Read ↗

Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.Semantic proximity Read ↗

Familial Alzheimer's disease-associated mutations block translocation of full-length presenilin 1 to the nuclear envelope.Semantic proximity Read ↗

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.Semantic proximity Read ↗

Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.Semantic proximity Read ↗

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.Semantic proximity Read ↗

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Semantic proximity Read ↗

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.Semantic proximity Read ↗

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations.Semantic proximity Read ↗

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