Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.

Gastroenterology - 1 Apr 2012

Galandiuk Susan, Rodriguez-Justo Manuel, Jeffery Rosemary, Nicholson Anna M, Cheng Yong, Oukrif Dahmane, Elia George, Leedham Simon J, McDonald Stuart A C, Wright Nicholas A, Graham Trevor A

Abstract excerpt

BACKGROUND & AIMS: Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with nondysplastic but tumorigenic clones) might contribute to intestinal carcinogenesis. We investigated patterns of tumor development from pretumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Clone Cells
Share to Colitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Intestinal Neoplasms

Share to Laser Capture Microdissection

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22178590
DOI: 10.1053/j.gastro.2011.12.004
PMCID: PMC4446968

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22178590-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.PMID 22178590Read ↗

Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.Semantic proximity Read ↗

Molecular mechanisms in colitis-associated colorectal cancerSemantic proximity Read ↗

Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development.Semantic proximity Read ↗

Clonal evolution of colorectal cancer in IBD.Semantic proximity Read ↗

Field cancerisation in colorectal cancer: A new frontier or pastures past?Semantic proximity Read ↗

Field cancerization in the GI tract.Semantic proximity Read ↗

Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancersSemantic proximity Read ↗

Dynamic tumor growth patterns in a novel murine model of colorectal cancer.Semantic proximity Read ↗

New insights into the earliest stages of colorectal tumorigenesis.Semantic proximity Read ↗

The initiation of colon cancer in a chronic inflammatory setting.Semantic proximity Read ↗

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.Semantic proximity Read ↗

Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.