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Article

MGMT promoter methylation and field defect in sporadic colorectal cancer.

Journal of the National Cancer Institute - 21 Sept 2005

Shen Lanlan, Kondo Yutaka, Rosner Gary L, Xiao Lianchun, Hernandez Natalie Supunpong, Vilaythong Jill, Houlihan P Scott, Krouse Robert S, Prasad Anil R, Einspahr Janine G, Buckmeier Julie, Alberts David S, Hamilton Stanley R, Issa Jean-Pierre J

Abstract excerpt

BACKGROUND: Sporadic colorectal cancers often arise from a region of cells characterized by a "field defect" that has not been well defined molecularly. DNA methylation has been proposed as a candidate mediator of this field defect. The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is frequently methylated in colorectal cancer. We hypothesized that MGMT methylation could be one of the mediators of...

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Identifiers

PMID: 16174854
DOI: 10.1093/jnci/dji275

Genes

MGMT
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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