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Article

Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

1 Feb 2019

Abstract excerpt

We used whole-organ mapping to study the locoregional molecular changes in a human bladder containing multifocal cancer. Widespread DNA methylation changes were identified in the entire mucosa, representing the initial field effect. The field effect was associated with subclonal low-allele frequency mutations and a small number of DNA copy alterations. A founder mutation in the RNA splicing gene, ACIN1, was...

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PMID: 30784602
DOI: 10.1016/j.celrep.2019.01.095

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