Article
WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 2005
Turner Stephen T, Schwartz Gary L, Chapman Arlene B, Boerwinkle Eric
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in genes encoding or influencing renal sodium transport systems were investigated as potential predictors of blood pressure (BP) response to a thiazide diuretic. A sample of 585 adults with essential hypertension (30 to 59.9 years of age; 50% blacks; 47% women) were treated with hydrochlorothiazide for 4 weeks (25 mg daily, orally) to determine office BP responses....
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