Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide.

American journal of hypertension - 1 Oct 2003

Turner Stephen T, Chapman Arlene B, Schwartz Gary L, Boerwinkle Eric

Abstract excerpt

BACKGROUND: Pharmacogenetic discoveries may enable greater individualization of antihypertensive drug therapy. We investigated polymorphisms in the genes encoding endothelial nitric oxide synthase (Glu298-->Asp), alpha-adducin (Gly460-->Trp), the beta(1)-adrenoceptor (Arg389-->Gly), beta2-adrenoceptor (Arg16-->Gly), and lipoprotein lipase (Ser447-->Stop) for their potential influences on blood pressure (BP)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Calmodulin-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diuretics

Share to Hydrochlorothiazide

Share to Hypertension

Share to Linear Models

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type III

Source

Identifiers

PMID: 14553962
DOI: 10.1016/s0895-7061(03)01011-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide.PMID 14553962Read ↗

Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects.Semantic proximity Read ↗

The effects of genes implicated in cardiovascular disease on blood pressure response to treatment among treatment-naive hypertensive African Americans in the GenHAT study.Semantic proximity Read ↗

Alpha-adducin polymorphism associated with increased risk of adverse cardiovascular outcomes: results from GENEtic Substudy of the INternational VErapamil SR-trandolapril STudy (INVEST-GENES).Semantic proximity Read ↗

Hypertension susceptibility loci and blood pressure response to antihypertensives: results from the pharmacogenomic evaluation of antihypertensive responses study.Semantic proximity Read ↗

WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic.Semantic proximity Read ↗

Genetic polymorphisms influencing antihypertensive drug responsesSemantic proximity Read ↗

Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini reviewSemantic proximity Read ↗

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.Semantic proximity Read ↗

Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension.Semantic proximity Read ↗

Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseasesSemantic proximity Read ↗

Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.Semantic proximity Read ↗

Genetic variation in renin predicts the effects of thiazide diuretics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.